Evidence map›Paper›PMID 42550316›Full record

ArticleJournal of molecular histology2026

Ferroptosis induction by curcumin through regulating the expression of glutathione peroxidase 4 in papillary thyroid carcinoma.

Li Ren, Haofeng Ding, Yun Sun, Shenzhen Zhou, Tongtong Li, Jingyi Xia, Zhigao Zhu, Mohan Geng, Bo Zhu, Congli Zhang

Erratum issuedAbstract read
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In one paragraph

Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Li Ren *Department of Nuclear Medicine, School of Laboratory Medicine, Bengbu Medical University, Bengbu, 233030, China.
Haofeng Ding *School of Clinical Medicine, Bengbu Medical University, Bengbu, 233030, China.
Yun SunSchool of Clinical Medicine, Bengbu Medical University, Bengbu, 233030, China.
Shenzhen ZhouSchool of Clinical Medicine, Bengbu Medical University, Bengbu, 233030, China.
Tongtong LiSchool of Clinical Medicine, Bengbu Medical University, Bengbu, 233030, China.
Jingyi XiaSchool of Clinical Medicine, Bengbu Medical University, Bengbu, 233030, China.
Zhigao ZhuSchool of Clinical Medicine, Bengbu Medical University, Bengbu, 233030, China.
Mohan GengSchool of Clinical Medicine, Bengbu Medical University, Bengbu, 233030, China.
Bo ZhuDepartment of Pathology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, China.
Congli ZhangDepartment of Anesthesiology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, China. 51435@bbmu.edu.cn.

Funding

Action Project for Training Young and Middle-aged Teachers in Anhui Province's Universities JNFX2024038General project of health research in Anhui Province AHWJ2024Aa10058Natural Science Project of Bengbu Medical University 2024byzd030the Major Project from The Key Project of Natural Science Foundation of Anhui Provincial Department of Education 2024AH051250, 2023AH051998, 2023AH052016
6 · The paper itself

Abstract

To clarify the role of glutathione peroxidase 4 (GPX4)-mediated ferroptosis in curcumin-treated papillary thyroid carcinoma (PTC) cells and explore the underlying mechanisms. GPX4 expression and clinical relevance were analysed in 54 PTC tissues by immunohistochemistry. B-CPAP cells were used to assess proliferation, migration, apoptosis and cell cycle after curcumin treatment. Ferroptosis was evaluated by detecting malondialdehyde (MDA), reactive oxygen species (ROS), Fe

Indexed as

CurcuminFerroptosisGene Expression Regulation, NeoplasticPhospholipid Hydroperoxide Glutathione PeroxidaseThyroid Cancer, PapillaryThyroid NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGlutathioneHumansMaleMiceCurcuminGlutathionePhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesB-CPAPCurcuminFerroptosisGlutathione peroxidase 4Papillary thyroid carcinoma

Identifiers

PMID42550316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.