ArticleMikrochimica acta2026
Direct coupling of commercial coated blades with low-temperature plasma ionization mass spectrometry by micro-solvent aided soft thermal desorption.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Coated blades have been widely used with ambient ionization mass spectrometry (AIMS) using electrospray as ionization source. This article explores the coupling of commercial blades, containing hydrophilic-lipophilic balance particles (HLB), with soft ionization by chemical reaction in transfer mass spectrometry using a dedicated thermal desorber as interface. Commercial HLB-blades use polyacrylonitrile to embed the sorptive particles in the coating, but this binder is not fully compatible with the high temperatures required to efficiently desorb semivolatile compounds, such as those selected in this work (cocaine, codeine, methadone, and methamphetamine). To overcome this limitation, a micro-solvent-aided soft thermal desorption is proposed. For this purpose, 4 µL of octanol is deposited on the blade before placing it in the desorber, thereby assisting the chemical elution of the analytes and enabling thermal desorption at mild conditions (about 100 °C) in 1.5 min. As proof-of-concept, this strategy has been used to determine the drugs mentioned above in saliva, with detection limits as low as 0.6 µg L
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