Evidence map›Paper›PMID 42550227›Full record

ArticleAnalytical and bioanalytical chemistry2026

Absolute quantification of synthetic DNA fragments spanning hundreds to thousands of base pairs using SEC coupled with ICP-MS.

Bodong Yang, Qing Zhao, Di Wang, Xian Chen, Song Lu, Yunhua Gao

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bodong YangSchool of Biotechnology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Qing ZhaoSchool of Biotechnology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.
Di WangCenter for Advanced Measurement Science, National Institute of Metrology, Chaoyang, Beijing, 100029, China.
Xian ChenCenter for Advanced Measurement Science, National Institute of Metrology, Chaoyang, Beijing, 100029, China.
Song LuCenter for Advanced Measurement Science, National Institute of Metrology, Chaoyang, Beijing, 100029, China. lusong@nim.ac.cn.
Yunhua GaoCenter for Advanced Measurement Science, National Institute of Metrology, Chaoyang, Beijing, 100029, China. gaoyh@nim.ac.cn.

Funding

National Key Research and Development Program of China 2023YFF0614603
6 · The paper itself

Abstract

Conventional inductively coupled plasma mass spectrometry (ICP-MS) merely measures total phosphorus within nucleic acid matrices and cannot resolve intact target DNA from degraded oligonucleotide fragments or matrix-originated phosphorus contaminants. In this work, we report a hyphenated size-exclusion chromatography-ICP-MS (SEC-ICP-MS) workflow for direct mass quantification of double-stranded DNA fragments spanning hundreds to thousands of base pairs. Purified DNA fragments are introduced directly via HPLC injection for size-based separation.

Indexed as

Absolute quantificationMass spectrometry/ICP-MSSynthetic DNA fragment

Identifiers

PMID42550227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.