Evidence map›Paper›PMID 42550076›Full record

ArticleInfection and immunity2026

Subunits of adaptor protein complex-1 make distinct contributions to the virulence of

Kabir Bhalla, Eddy Sánchez-León, Yu-Hsuan Huang, Guanggan Hu, Anisha Neogi, Alba Torres-Cano, Oscar Zaragoza, Pauline Johnson, James W Kronstad

Abstract read
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kabir Bhalla *Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7645-3725
Eddy Sánchez-León *Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-1571-2361
Yu-Hsuan HuangDepartment of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada.
Guanggan HuMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Anisha NeogiMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Alba Torres-CanoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Oscar ZaragozaCenter for Biomedical Research in Network in Infectious Diseases (CIBERINFEC-CB21/13/00105), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-1581-0845
Pauline JohnsonDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
James W KronstadMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-4240-6976

Funding

Comparative and functional genomics of C. neoformansR01AI053721 · NIAID · UNIVERSITY OF BRITISH COLUMBIA · PI KRONSTAD, JAMES W · 2003 to 2024
$5.4M
CIHR PJT-166043Natural Sciences and Engineering Research Council of Canada RGPIN 2022-04795NIAID NIH HHS R01 AI053721NIH HHS R01AI053721
6 · The paper itself

Abstract

Cryptococcal meningoencephalitis is among the most prevalent invasive fungal diseases, posing a threat to immunocompromised individuals and representing a growing global health concern. The mechanisms of cryptococcal trafficking of virulence factors during disease are incompletely understood. Adaptor protein (AP) complexes play crucial roles in intracellular trafficking by orchestrating the sorting of macromolecular cargo and serving as essential components of the endocytic and secretory pathways. In a recent study, we demonstrated that

Indexed as

Adaptor Protein Complex 1CryptococcosisCryptococcus neoformansProtein SubunitsAnimalsDisease Models, AnimalFemaleLungMacrophagesMiceMice, Inbred C57BLVirulenceVirulence FactorsAdaptor Protein Complex 1Protein SubunitsVirulence Factorscytokinesendomembrane traffickingfungal pathogenesisgranulomaphagocytosis

Identifiers

PMID42550076
PMCPMC13552105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.