Evidence map›Paper›PMID 42550002›Full record

ArticleJournal of Korean medical science2026

Serum Interferon-γ Is Associated With Refractory

Hye Young Han, Jeong-Min Oh, Jung-Woo Rhim, Mea-Young Chang, Eun-Ae Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hye Young HanDepartment of Pediatrics, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-2246-4709
Jeong-Min OhClinical Research Institute, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.ORCID https://orcid.org/0009-0003-5553-2549
Jung-Woo RhimDepartment of Pediatrics, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-0227-3809
Mea-Young ChangDepartment of Pediatrics, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.ORCID https://orcid.org/0000-0001-5368-3296
Eun-Ae YangDepartment of Pediatrics, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-4787-5763

Funding

Clinical Research Institute, Daejeon St. Mary's Hospital, The Catholic University of Korea
6 · The paper itself

Abstract

background

methodsA total of 53 patients with MP pneumonia and 9 patients with viral pneumonia patients were enrolled. Point mutations at residues 2063, 2064, and 2067 in domain V of 23S rRNA gene were analyzed, and serum levels of interferon (IFN)-γ, interleukin (IL)-6, TNF-α, IL-10, and IL-1β were measured before and after steroid treatment.

resultsThere was no significant difference in serum cytokine concentrations between the MP pneumonia group and the viral pneumonia group. The A2063G point mutation was identified in 72% (18/25) of tested MP pneumonia patients. IFN-γ and IL-6 levels showed significant positive correlations with the duration of hospitalization, fever after admission and duration of steroid treatment. The macrolide-resistant MP (MRMP) group tended to have higher IFN-γ levels than the macrolide-sensitive MP group (

conclusionTherefore, IFN-γ may serve as a valuable biomarker for predicting a refractory clinical course of MP pneumonia. In addition, LDH and AST levels, which showed the closest correlation to IFN-γ and IL-6, may also be proposed as indicators of disease severity.

Indexed as

Interferon-gammaPneumonia, MycoplasmaAnti-Bacterial AgentsChildChild, PreschoolDrug Resistance, BacterialFemaleHumansInterleukin-10Interleukin-1betaInterleukin-6MacrolidesMaleMycoplasma pneumoniaePneumonia, ViralPoint MutationAnti-Bacterial AgentsInterferon-gammaInterleukin-10Interleukin-1betaInterleukin-6MacrolidesRNA, Ribosomal, 23SSteroidsTumor Necrosis Factor-alphaChildInterferon-γMycoplasma pneumoniaePneumonia

Identifiers

PMID42550002
PMCPMC13433647

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.