Observational studyJournal of Korean medical science2026
Cement Use in Bipolar Hemiarthroplasty and Its Association With Cancer Risk.
Observational study in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06307145 (Efficacy and Safety of Hip Replacement Surgery Using Korean National Registry), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Hip Replacement Surgery Using Korean National Registry
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Authors and funding
6 authors.
Funding
Abstract
backgroundPrevious studies have been unable to confirm a direct relationship between polymethylmethacrylate use and cancer risk in hemiarthroplasty (HA) due to a lack of differentiation between cemented and cementless fixation in cancer risk assessment. This study aimed to clarify this by examining the incidence of cancer in patients who underwent cemented HA compared to those who received cementless HA.
methodsThis study was a retrospective nationwide cohort study using the Korean National Health Insurance Service database, which represents nearly the entire Republic of Korea (South Korea) population. We included adult patients aged over 19 years who underwent HA between January 1, 2003, and December 31, 2019 (N = 160,394). Patients with previous revision surgeries, bilateral procedures, or prior cancer history were excluded. Cemented and cementless groups were defined based on the type of femoral stem used. The primary outcome was the incidence of cancer, measured through cancer-specific insurance codes and cancer diagnosis codes. Kaplan-Meier curves and Cox proportional hazards models were used to evaluate cancer risk differences between cemented and cementless HA groups.
resultsAmong the patients, 37.6% underwent HA with cemented fixation. During a follow-up period of up to 12 years, no significant differences were observed between the cemented and cementless groups in the risk of developing any cancer, solid tumors, or hematologic cancers. However, the cemented group had a 1.8-fold (95% confidence interval [CI], 1.12-2.99) increased risk of multiple myeloma compared to the cementless group. This association was particularly pronounced among patients under 70 years of age (adjusted hazard ratio, 3.44; 95% CI, 1.10-10.82) relative to those aged 70 or older.
conclusionPatients who underwent cemented HA showed a higher risk of multiple myeloma than those who received cementless HA. The association between cement use and multiple myeloma was especially evident in younger patients. These findings highlight the importance of evaluating long-term risks associated with cemented HA to inform safer surgical approaches and guide treatment selection.
trial registrationClinicalTrials.gov Identifier: NCT06307145.
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