ArticlemBio2026
SpxA1 and SpxA2 function as a stoichiometry-dependent regulatory rheostat governing virulence gene expression in group A
Gretchen A Morrison, Luis Alberto Vega, Misú Sanson Iglesias, Khufu Holly, W Hayes McDonald, Nicola Horstmann, Samuel A Shelburne, Jennifer A Gaddy, Anthony R Flores
Abstract read
In one paragraphArticle in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Gretchen A MorrisonDivision of Pediatric Infectious Diseases, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Luis Alberto VegaDepartment of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Misú Sanson IglesiasDivision of Pediatric Infectious Diseases, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Khufu HollyDivision of Pediatric Infectious Diseases, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
W Hayes McDonaldMass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Nicola HorstmannDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Samuel A ShelburneDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9721-263X Jennifer A GaddyDivision of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-2192-4224 Anthony R FloresDivision of Pediatric Infectious Diseases, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-6402-4269 Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MVANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced GenomicsG20RR030956 · NCRR · VANDERBILT UNIVERSITY · PI PIETENPOL, JENNIFER A · 2010 to 2010
$8.7MModular Automated -80C Sample Storage SystemS10OD025092 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOLDENRING, JAMES RICHARD · 2019 to 2019
$2.0MContribution of LiaFSR to pathogenesis and carriage of group A StreptococcusR01AI125216 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FLORES, ANTHONY RICHARD · 2017 to 2021
$1.9MDelineation of mechanisms underlying response regulator activation in group A StreptococcusR21AI177931 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHELBURNE, SAMUEL A · 2024 to 2025
$439kNational Institute of Allergy and Infectious Diseases R01AI125216National Institute of Allergy and Infectious Diseases R21AI177931NCI NIH HHS P30 CA068485NCRR NIH HHS G20 RR030956NEI NIH HHS P30 EY008126NIAID NIH HHS R01 AI125216NIAID NIH HHS R21 AI177931NIH HHS S10 OD025092
6 · The paper itselfAbstract
Group A IMPORTANCE: Group A
Indexed as
Bacterial ProteinsGene Expression Regulation, BacterialStreptococcus pyogenesTranscription FactorsVirulence FactorsGene Expression ProfilingHumansOxidative StressProteomicsRegulonVirulenceBacterial ProteinsTranscription FactorsVirulence Factorscell envelope stress responseChIP-exoCovRS two-component systemgroup A StreptococcusSpx transcriptional regulator
Identifiers
PMID42549902
PMCPMC13556197
What OpenQuestion holds
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