ArticleCNS neuroscience & therapeutics2026
An Olfactory Piriform Cortex-Lateral Hypothalamus Neural Circuit Contributes to Linalool-Induced Analgesia.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
aimsAromatherapy-mediated analgesia is widely applied, but the underlying neural mechanisms remain poorly understood. This study aimed to investigate the neurobiological basis underlying linalool-induced attenuation of inflammatory pain.
methodsA complete Freund's adjuvant (CFA)-induced hind-paw inflammatory pain model was used to evaluate the antinociceptive effects of linalool odor exposure through mechanical and thermal nociceptive threshold tests, together with conditioned place preference. Viral tracing, in vivo fiber photometry, electrophysiological recordings, and chemogenetic or optogenetic manipulations were employed to identify and functionally characterize the neural circuits underlying linalool-induced analgesia.
resultsLinalool odor exposure increased mechanical and thermal nociceptive thresholds and induced pain relief-associated place preference in CFA mice. Linalool exposure activated orexin A-expressing neurons in the lateral hypothalamus (LH
conclusionOur study identified an olfactory cortex-hypothalamic circuit contributing to linalool-induced antinociceptive effects, providing mechanistic insight into olfactory modulation of inflammatory pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.