Evidence map›Paper›PMID 42549659›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Lower cardiac output is a risk factor for faster cerebral atrophy over a 11-year follow-up period in APOE-ε4 carriers.

Elizabeth E Moore, Panpan Zhang, Omair A Khan, Dandan Liu, Deepak K Gupta, Kimberly R Pechman, Katherine A Gifford, Bennett A Landman, Timothy J Hohman, Angela L Jefferson

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Elizabeth E MooreDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.
Panpan ZhangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Omair A KhanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Dandan LiuVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Deepak K GuptaDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kimberly R PechmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Katherine A GiffordDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Bennett A LandmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Angela L JeffersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Funding

Alzheimer's Association IIRG-08-88733Award S10-OD023680National Institute of Health R01-NS100980;R01-AG062826National Institute of Health T32-GM007447National Institute of Health UL1-TR000445NCATS NIH HHS UL1-TR002243NIA NIH HHS F30-AG064847NIA NIH HHS K24-AG046373NIA NIH HHS P30-AG086403NIA NIH HHS R01-AG034962Vanderbilt Alzheimer's Disease Research Center S10-OD021771Vanderbilt Clinical Translational ScienceVanderbilt's High-Performance Computer Cluster for Biomedical Research P20-AG068082VUIIS Center for Human Imaging
6 · The paper itself

Abstract

introductionSubclinical lower cardiac output (volume of blood pumped per minute) cross-sectionally relates to smaller cerebral gray matter volumes in older adults. This study relates cardiac output to longitudinal gray matter volumes among middle-aged and older adults over an 11-year period.

methodsLinear regression (cross-sectional) and mixed effects (longitudinal) models related baseline cardiac output to gray matter volume trajectory, adjusting for demographic factors. Secondary models tested cardiac output × apolipoprotein E (APOE) -ε4 status interactions.

resultsLower cardiac output related to smaller brain volumes (p-values < 0.04) in APOE-ε4 positive participants only. In longitudinal models, baseline cardiac output interacted with APOE-ε4 status (p = 0.006). Lower baseline cardiac output related to greater increase in inferior lateral ventricle volume over time in APOE-ε4 carriers (p = 0.01) only. DISCUSSION: Results suggest among APOE-ε4 carriers, subclinical cardiac dysfunction relates to greater neurodegeneration cross-sectionally and longitudinally. However, results must be interpreted with caution and replicated.

Indexed as

Apolipoprotein E4BrainCardiac OutputAgedAtrophyCross-Sectional StudiesFemaleFollow-Up StudiesGray MatterHeterozygoteHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsApolipoprotein E4APOEbrain MRIcardiac outputgray matterneurodegeneration

Identifiers

PMID42549659
PMCPMC13435374

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.