ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
Prognostic Value of the P16/P53 Immunohistochemical Association in Oropharyngeal Squamous Cell Carcinomas.
Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
importanceAccurate HPV status diagnosis is essential for managing oropharyngeal squamous cell carcinoma.
objectiveWe aimed to refine HPV status determination using a cost-effective and reliable approach by integrating the p53 immunohistochemical marker with the conventional p16 marker. We assessed the association between HPV status and the p16/p53 tumor immunohistochemical status and analyzed patient survival based on p16/p53 expression.Design, Setting, Participants, and Exposures:This retrospective, single-center study included 285 patients with oropharyngeal squamous cell carcinoma (2017-2022) with known p16/p53 immunohistochemical profiles. In a subset of 92 patients, HPV status was formally determined using polymerase chain reaction or in situ hybridization. OUTCOME MEASURES AND
resultsThe p16/p53 test was an excellent predictor of HPV status (specificity: 100%, sensitivity: 98.48%), significantly outperforming p16 alone (
conclusionThe p16/p53 immunohistochemical profile appears to be a reliable surrogate marker for HPV status and a strong predictor of survival. It could help identify discordant cases, helping prevent inappropriate therapeutic de-escalation. RELEVANCE: With the advancement of artificial intelligence, integrating additional markers into an algorithmic analysis could further refine patient classification and enable more personalized therapeutic approaches.
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