Evidence map›Paper›PMID 42549082›Full record

ArticleBeilstein journal of nanotechnology2026

Ultrasonic irradiation in the synthesis of nanohydroxyapatite: a chemically friendly technique for improving hemocompatibility and antibiofilm applications.

Juan Mendoza Turmero, Cristina Parra Pantoja, Marcos Sabino Gutiérrez, Milagro Fernández-Delgado, Claudia Alvarado-Castillo, Damarys Soto Gil, María E Gomes Gomes, Yony Gutiérrez Barrios, Daniel Suárez Arteaga

Abstract read
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In one paragraph

Article in Beilstein journal of nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan Mendoza TurmeroDepartment of Materials Science, Simón Bolívar University, Caracas, Venezuela.ORCID https://orcid.org/0009-0007-3015-8414
Cristina Parra PantojaFunctional Nanostructured Materials Laboratory, Center for Materials Engineering and Nanotechnology, Venezuelan Institute for Scientific Research (IVIC). Miranda State, Venezuela.ORCID https://orcid.org/0009-0004-1190-7449
Marcos Sabino GutiérrezDepartment of Chemistry, B5ida Group, Simón Bolívar University, Caracas, Venezuela.ORCID https://orcid.org/0000-0001-8316-7241
Milagro Fernández-DelgadoBionanotechnology Laboratory, Center for Materials Engineering and Nanotechnology, IVIC. Miranda State, Venezuela.ORCID https://orcid.org/0000-0001-6111-1116
Claudia Alvarado-CastilloLaboratory of Hemostasis and Vascular Genetics, Center for Biophysics and Biochemistry, IVIC. Miranda State, Venezuela.ORCID https://orcid.org/0000-0002-1352-2524
Damarys Soto GilNanomaterials Characterization Laboratory, Center for Materials Engineering and Nanotechnology, IVIC. Miranda State, Venezuela.ORCID https://orcid.org/0009-0006-2613-7672
María E Gomes GomesFunctional Nanostructured Materials Laboratory, Center for Materials Engineering and Nanotechnology, Venezuelan Institute for Scientific Research (IVIC). Miranda State, Venezuela.ORCID https://orcid.org/0009-0005-2440-1794
Yony Gutiérrez BarriosBionanotechnology Laboratory, Center for Materials Engineering and Nanotechnology, IVIC. Miranda State, Venezuela.ORCID https://orcid.org/0009-0008-4681-1446
Daniel Suárez ArteagaLaboratory of Hemostasis and Vascular Genetics, Center for Biophysics and Biochemistry, IVIC. Miranda State, Venezuela.ORCID https://orcid.org/0009-0007-2036-9664

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the synthesis of nanohydroxyapatite (nHA) using high-frequency ultrasonic irradiation (UI), a chemically friendly technique aligned with green chemistry principles. Synthesis was achieved by varying the UI time (15, 30, 45, and 60 min) and the reaction medium. Water-based mixtures were used, that is, water/acetone (W/ACET), water/tetrahydrofuran (W/THF), and water/ethanol (W/ETOH). The resulting nHA was characterized structurally using FTIR, XRD, TGA, FESEM, and specific surface area determination. These analyses revealed the formation of carbonated nHA similar to biological apatite, with distinct morphologies and particle sizes dependent on the solvent system used. All synthesized materials exhibited high thermal stability and yields exceeding 80%. Hemocompatibility studies showed that nHA samples obtained in the W/THF mixture presented very low hemotoxicity (hemolysis < 2%), and did not affect platelet ADP aggregation processes. Microbiological assays showed a significant reduction in

Indexed as

antibiofilm propertieshemocompatibilitynanohydroxyapatiteultrasonic irradiation

Identifiers

PMID42549082
PMCPMC13430526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.