ReviewFrontiers in immunology2026
Mechanistic insights into ferroptosis and its therapeutic potential in hepatocellular carcinoma.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Ferroptosis is an iron-dependent form of programmed cell death driven by lipid peroxidation, distinct from apoptosis and necrosis. It has been confirmed as a key regulator in hepatocellular carcinoma (HCC). This study systematically elucidates three interconnected regulatory networks of ferroptosis-metabolic, epigenetic, and microenvironmental-and proposes a closed-loop regulatory model integrating these dimensions. By integrating metabolic biomarkers, epigenetic indicators, and microenvironmental features, we also summarize emerging strategies to enhance ferroptosis sensitivity. By summarizing the regulatory nodes as well as clinical translation progress, this work provides a comprehensive roadmap for overcoming therapeutic bottlenecks in HCC and realizing ferroptosis-based precision medicine.
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