ArticleEuropean journal of obstetrics & gynecology and reproductive biology: X2026
Investigation of the effect of intrauterine injection of platelet-rich plasma (PRP) on the results of in vitro fertilization (IVF): A cohort study.
Article in European journal of obstetrics & gynecology and reproductive biology: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Recurrent implantation failure (RIF) is among the biggest problems in assisted reproductive treatments. Recently, there is a suggestion of intrauterine injection of platelet-rich plasma (PRP) as a novel method of enhancing endometrial receptivity, but there exists a lack of controlled evidence in this field. This study was conducted to examine the effectiveness and safety of intrauterine PRP injection on fertility rates of women with RIF undergoing frozen-thawed embryo transfer (FET) cycles. This is a retrospective cohort study that examined 100 women with RIF who had an age of 21-42 years and were studied in Nahal Infertility Center, Sayyad Shirazi Hospital (Gorgan, Iran) in 2023. Patients were divided into two intervention groups (n = 51) and were intrauterinely injected with autologous PRP 48 h prior to embryo transfer and a control group (n = 49) which only underwent regular FET treatment. Clinical pregnancy rate was the main outcome and the secondary outcomes were implantation rate, miscarriage, live birth and endometrial thickness. Independent t-tests, chi-square and logistic regression were used to statistically analyze the data. The clinical pregnancy rate was more significant in the intervention group compared to the control group (27.45% vs. 8.16; OR = 4.29; 95% CI: 1.32-13.92; P = 0.001). The PRP group also showed the highest rate of implantation (25.5% vs. 8.2; P = 0.008). There were no significant differences in miscarriage rates and perinatal complications. Also, No adverse events related to PRP injection were reported. PRP Intrauterine injection has the potential to boost pregnancy rates in RIF women, regardless of the endometrial thickness. This is a safe, inexpensive and applicable in infertility centers, and as an adjunctive intervention in IVF procedures.
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