Evidence map›Paper›PMID 42548968›Full record

ArticleIranian journal of public health2025

Association between the Blood-Inflammatory Index with Depression and Anxiety in a Large Population.

Mina Nosrati, Hossein Hatamzadeh, Amin Mansoori, Mahsa Tousi, Shakiba Najjar Khalilabad, Fateme Rojoee, Fatemeh Mohammadyari, Gordon A Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan

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Article in Iranian journal of public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mina NosratiInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein HatamzadehDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Amin MansooriDepartment of Applied Mathematics, Ferdowsi University of Mashhad, Mashhad, Iran.
Mahsa TousiDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Shakiba Najjar KhalilabadStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fateme RojoeeStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh MohammadyariSchool of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Gordon A FernsDepartment of Medical Education, Brighton and Sussex Medical School, Brighton, United Kingdom.
Habibollah EsmailySocial Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid Ghayour-MobarhanInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inflammatory indices have been linked to mood disorders. We aimed to examine whether these inflammatory indices are associated with the severity of depression and anxiety as measured by Beck scores. Methods: This cross-sectional analysis included 9,704 participants aged 35-65 years from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. Depression and anxiety were assessed using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Inflammatory indices were calculated based on hematological and biochemical parameters. Multinomial logistic regression was applied to evaluate the associations between inflammatory markers and mood disorder severity. Results: In cases of severe depression, the neutrophil-to-lymphocyte ratio (NLR), white blood cell (WBC) count, and serum high-sensitivity C-reactive protein (hs-CRP) levels were significantly higher (OR = 1.29, 1.08, and 1.01, respectively; Conclusion: Higher levels of depression were associated with increased inflammatory hematological indices, and that the severity of depression was related to elevated levels of NLR, WBC, and hs-CRP.

Indexed as

AnxietyBloodC-Reactive proteinDepressionInflammation

Identifiers

PMID42548968
PMCPMC13430118

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