ArticleiScience2026
SCLC humanized mice identify T cell infiltration phenotypes in response to combination immune-radiation therapies.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Molecular small cell lung cancer (SCLC) subtypes (ASCL1, NEUROD1, POU2F3, and inflamed) display distinct immune contextures, but preclinical modeling remains limited. We evaluated peripheral blood mononuclear cell (PBMC) humanized mice (hu-mice) as a platform to capture subtype-specific tumor-immune interactions and therapeutic sensitivity to the triplet regimen: AZD1390 (ATM inhibitor), radiotherapy (RT), and durvalumab (aPDL1). SCLC cell lines representing all molecular subtypes were engrafted into hu-mice, and while T cell infiltration varied across subtypes, SCLC-inflamed cell lines exhibited the highest levels of infiltration. Infiltrating CD8
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