ArticleFrontiers in oncology2026
Case Report: Short-term disease control with subsequent icotinib therapy in EGFR L858R/C797S, T790M-negative lung adenocarcinoma after osimertinib resistance.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osimertinib resistance, particularly EGFR C797S without T790M, lacks established treatment strategies. We report a 71-year-old woman with stage IVB lung adenocarcinoma harboring EGFR L858R (T790M-negative) who received first-line osimertinib for 29 months until progression. Post-progression ctDNA revealed L858R/C797S (T790M-negative) who received first-line osimertinib for 29 months until progression. Post-progression ctDNA revealed L858R/C797S (T790M-negative). She was subsequently treated with icotinib 125 mg tid, achieving stable disease for 6 months. This case suggests that first-generation EGFR-TKI subsequent therapy may provide short-term disease control in this rare molecular context.
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