ArticleFrontiers in neurology
Association between peripheral blood T cell subsets and clinical disability in multiple sclerosis patients.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Multiple sclerosis (MS) is a chronic immune-mediated disorder involving complex interactions among adaptive and innate immune pathways. The relationship between peripheral blood T cell subsets and clinical disability remains inadequately characterized. This study investigated associations between T cell subsets (CD4+, CD8+, CD4+/CD8 + ratio) and Expanded Disability Status Scale (EDSS) scores in MS patients. Methods: We conducted a cross-sectional study of 48 MS patients who underwent EDSS scoring and flow cytometric analysis of peripheral blood T cell subsets. Clinical and treatment-related characteristics were also collected. Correlations between T cell parameters and EDSS scores were analyzed using Spearman correlation and multivariable linear regression. Exploratory sensitivity analyses were performed to evaluate the potential influence of disease-modifying therapy (DMT) exposure on the association between CD4+/CD8 + ratio and EDSS. Results: Forty-eight MS patients (mean age 35.1 ± 5.8 years, 72.9% female) with mean EDSS score of 3.20 ± 1.50 were included. Mean CD4+/CD8 + ratio was 2.76 ± 1.08 and correlated negatively with EDSS scores ( Conclusion: CD4+/CD8 + ratio was negatively associated with clinical disability in this cross-sectional MS cohort, and stratified analysis showed a progressive decline across disability severity groups. These findings suggest that CD4+/CD8 + ratio may represent an exploratory peripheral immune indicator associated with disability status in MS.
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