Trial reportFrontiers in cardiovascular medicine2026
Effects of HIIT and MICT on cardiovascular function in essential hypertension: roles of inflammation, oxidative stress, and RAS axis.
Trial report in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise in Patients with Subclinical Atherosclerosis: Mechanisms, Clinical Evidence, and Practical Recommendations.Current atherosclerosis reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare the effects of High Intensity Interval Training (HIIT) and Moderate Intensity Continuous Training (MICT) on blood pressure homeostasis, cardiovascular structure, and function, and to explore the underlying neuro-humoral regulatory mechanisms in patients with essential hypertension (EH). Methods: A total of 56 EH patients were randomly (1:1) assigned to the MICT (35 min) or HIIT (1 × 10 min with 2 min intervals) for 8 weeks, three times per week. The primary outcome was the change in flow-mediated dilation (FMD). Blood pressure, traditional cardiovascular risk factors, cardiovascular structure and function, as well as neural, specific humoral, and nonspecific humoral regulation were assessed. Results: Among 56 patients with EH who were randomized, 54 (96.4%) completed the 8-week evaluation. After an 8-week intervention, the improvement in FMD was significantly greater in the HIIT group compared with the MICT group (mean difference: 0.85% [95% CI, 0.50-1.21]). HIIT showed favored changes in nitric oxide, FMD, and endothelin-1, brachial-ankle pulse wave velocity, peak systolic velocity, corrected QT Interval, Ratio of Early Diastolic Mitral Valve Peak Flow Velocity to Early Diastolic Myocardial Velocity, angiotensin-(1-7), and C-reactive protein in EH patients (all Conclusion: Both HIIT and MICT yielded comparable effects on lowering systolic blood pressure and regulating neurohumoral factors. FMD was improved to a greater extent with HIIT, which also showed superior efficacy in arterial stiffness, hemodynamics, cardiac diastolic function, and inflammatory biomarkers. Clinical Trial Registration: https://www.chictr.org.cn, identifier ChiCTR2500097077.
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