ArticleFrontiers in pediatrics2026
Clinical and laboratory characteristics of critical
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Background: Critical pertussis remains a critical health concern in infants and is characterized by severe leukocytosis, respiratory failure, and multisystem involvement. Despite global vaccination efforts, outbreaks continue to occur, particularly among unvaccinated or partially vaccinated infants. This study aimed to describe the clinical, laboratory, and management characteristics of critically ill infants with critical Materials and methods: A retrospective cohort study was conducted involving 70 infants hospitalized for severe pertussis between January 2024 and April 2025. Data collected included demographic details, presenting symptoms, comorbidities, vital signs, laboratory parameters [e.g., white blood cell (WBC) count, inflammatory markers, liver enzymes], treatments received (e.g., macrolides, exchange transfusions, leukoreduction therapies), and clinical outcomes. Statistical analyses included descriptive statistics and comparative tests ( Results: Among the 70 infants, the median age was 3 months, with 46.4% of the infants aged < 3 months. Non-survivors ( Conclusion: Critical pertussis primarily affects unimmunized infants <3 months and is associated with severe illness and a notable fatality rate despite intensive care. Strengthening maternal and infant immunization, along with early risk identification and prompt intervention, is essential. Further research and public health efforts are needed to reduce disease burden.
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