ReviewFrontiers in oncology2026
Social genomics and cancer - untangling nature from nurture in squamous cell carcinoma outcomes.
Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Outcomes in squamous cell carcinomas (SCCa) of the head and neck, esophagus, and lungs are increasingly linked to the complex interplay between social determinants of health (SDoH) and biological pathways. The emerging field of social genomics provides mechanistic insight into how the environmental and socioeconomic conditions may influence tumor biology through stress-mediated pathways, epigenetic modifications, and altered gene expression. Objective: This review explores the role of adverse socioeconomic conditions such as neighborhood deprivation in shaping SCCa outcomes and the potential underlying mechanisms. In response to chronic stress, hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system become activated, leading to dysregulated immune signaling and proinflammatory gene expression pattern collectively known as the Conserved Transcriptional Response to Adversity (CTRA). We discuss epigenetic modifications including DNA methylation (DNAm), histone modification, and micro RNA (miRNA) dysregulation as potential mediators of these stress-related effects. Studies show that SCCa may have distinct race- and neighborhood-specific DNAm patterns including differential methylation of Conclusion: Social genomics provides a deeper understanding of the interaction of socio-environmental exposures with the epigenome and tumor biology influencing disparities in SCCa outcomes. Future research should integrate geospatial and multi-omics data to inform personalized cancer prevention and treatment strategies.
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