ArticleCHEST pulmonary2025
Treatment With Bilevel PAP Is Associated With a Reduction in Severe Exacerbations in COPD-OSA Overlap: A Retrospective Claims Analysis.
Article in CHEST pulmonary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Breath of Fresh Air: A New Analysis of an Age-Old Question.CHEST pulmonary · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There are no guidelines for OSA assessment in patients with COPD. Home noninvasive ventilation (NIV) studies have excluded patients with comorbid OSA. Thus, it is unclear whether home NIV is associated with reduced exacerbation risk in patients with overlap syndrome. Research Question: Does home NIV impact the rate of severe exacerbations in patients with overlap syndrome 1 year after therapy initiation? Study Design and Methods: A retrospective analysis was performed on administrative claims data from patients with COPD and OSA who received an NIV device claim between 2015 and 2020. Patients were characterized 1 year before NIV initiation and 1 year after NIV initiation. A modified Poisson regression model was built to identify predictors for severe exacerbation occurrence during follow-up. Results: A total of 23,992 patients were included in the analysis (mean age, 61.3 ± 10.1 years; 44.9% female). The proportion of patients with ≥ 1 severe exacerbation was 10.2% in the year before NIV initiation and 5.9% in the year after NIV initiation (χ Interpretation: To our knowledge, this is the first study to describe risk factors for severe exacerbations and to examine home NIV claims in this specific population. Results may be informative for overlap syndrome management, especially for preventing a first severe exacerbation and for the treatment of OSA as part of COPD management. Additional information is needed to optimize the access, timing, and benefits of NIV treatment in patients with overlap syndrome.
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