ArticleFrontiers in medicine2026
The value of mNGS in the diagnosis of central nervous system infections in immunodeficient hosts with decompensated cirrhosis complicated by
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The incidence of central nervous system (CNS) infections caused by Case presentation: A 62-year-old male with a 7-year history of cirrhosis presented with fever, headache, and loss of consciousness. At admission, the patient was in a decompensated state with a Child-Pugh score of 9 (Grade B) and a Model for End-Stage Liver Disease (MELD) score of 12, characterized by hypoalbuminemia and mild ascites. Diagnosis and intervention: To avoid delayed treatment, broad-spectrum antibiotics were used before the results of blood and cerebrospinal fluid cultures were available. Preliminary cerebrospinal fluid (CSF) analysis showed an atypical inflammatory response in the context of cirrhosis-associated immune dysfunction. Although conventional CSF cultures remained negative, mNGS detected Conclusion: Cirrhosis-associated immune dysfunction (CAID) and hypersplenism can mask typical CSF diagnostic markers. mNGS provides a rapid, unbiased diagnostic paradigm that is crucial for shortening diagnostic duration and guiding precision therapy in immunocompromised hosts.
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