ArticleFrontiers in dementia2026
A feasibility pilot study on the effects of a combined cognitive and physical intervention program in older adults in Panama.
Article in Frontiers in dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Introduction: Latin America and the Caribbean are experiencing rapid population aging, accompanied by rising dementia prevalence. Risk is heightened by social inequalities, low education, and limited healthcare resources. While pharmacological treatments for dementia prevention offer only modest benefits, non-pharmacological multimodal interventions have shown promise for maintaining cognition. However, such programs have not yet been evaluated in Panama. This pilot study examined the feasibility and effects of a multimodal physical and cognitive intervention program on cognition, depressive symptoms, and physical performance in community-dwelling older adults in Panama. Methods: Forty-three sedentary adults aged 60-80 were divided into three groups: combined cognitive-physical intervention group (CG; Results: Mixed-model ANCOVAs, adjusted for age and education, revealed no significant group-by-time interactions for MoCA, GDS-15, or SPPB. Nonetheless, descriptive analyses indicated the greatest numerical improvements in the CG (MoCA: +3.4 points; GDS-15: -1.1 points). Repeated-measures ANOVAs showed significant overall gains in cognition [ Discussion: This study demonstrates the feasibility of delivering multimodal interventions in Panama. Preliminary trends suggest potential cognitive and emotional benefits of combined approaches. Larger, longer trials are needed to confirm efficacy and optimize intervention design.
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