Evidence map›Paper›PMID 42548515›Full record

ArticleCHEST pulmonary2023

Outcomes Associated With Catheter-Directed Therapies in Chronic Thromboembolic Pulmonary Hypertension: Cautionary Tales From a Single-Center Case Series.

Jenny Z Yang, Nick H Kim, Seth Kligerman, Timothy M Fernandes, Demosthenes G Papamatheakis, David S Poch, Mona Alotaibi, Victor G Pretorius, Michael M Madani, Kim M Kerr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CHEST pulmonary, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jenny Z YangDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Department of Surgery, University of California, San Diego, La Jolla, CA.
Nick H KimDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Department of Surgery, University of California, San Diego, La Jolla, CA.
Seth KligermanDivision of Cardiothoracic Imaging, Department of Radiology, University of California, San Diego, La Jolla, CA.
Timothy M FernandesDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Department of Surgery, University of California, San Diego, La Jolla, CA.
Demosthenes G PapamatheakisDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Department of Surgery, University of California, San Diego, La Jolla, CA.
David S PochDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Department of Surgery, University of California, San Diego, La Jolla, CA.
Mona AlotaibiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Department of Surgery, University of California, San Diego, La Jolla, CA.
Victor G PretoriusDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA.
Michael M MadaniDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA.
Kim M KerrDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Department of Surgery, University of California, San Diego, La Jolla, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Catheter-directed therapies (CDTs) for acute pulmonary embolism (PE) are becoming increasingly popular. Although potentially beneficial in acute PE, CDT is ineffective for chronic thromboembolic disease. Herein we present our experience of patients with subsequently confirmed chronic thromboembolic pulmonary hypertension (CTEPH) or pulmonary artery sarcoma who initially received CDT before referral for surgical intervention. Research Question: How often is CDT being used in patients with CTEPH or pulmonary artery tumor, and what are the associated outcomes? Study Design and Methods: Retrospective review of all pulmonary thromboendarterectomy surgeries performed at the University of California, San Diego, from January 1, 2020, through December 31, 2021. Results: Three hundred fifty-four pulmonary thromboendarterectomy surgeries were performed during the study period. Fifty-two patients received CDT before referral (15%). Before CDT attempt, duration of dyspnea ranged from 3 days to 10 years and mean right ventricular systolic pressure measured by echocardiography was 75 ± 23 mm Hg. After CDT, mean right ventricular systolic pressure was 77 ± 23 mm Hg. Three patients reported full recovery of symptoms, 23 patients reported some improvement, and 26 patients reported no change in symptoms. Imaging at time of CDT was available for review for 32 patients; 23 patients showed radiologic evidence of CTEPH and three patients showed evidence suspicious of sarcoma. Complications associated with CDT occurred in seven patients (13%) and included one death. Interpretation: Radiologic signs of CTEPH frequently were overlooked at the time of CDT. Most patients (94%) achieved minimal or no improvement in symptoms after CDT, and 13% experienced complications. It is important to assess for clinical and radiologic signs of CTEPH when considering CDT in presumed acute PE to minimize unnecessary risk and instead refer patients for CTEPH evaluation.

Indexed as

catheter-directed thrombolysiscatheter suction thrombectomyCTEPHpulmonary embolism

Identifiers

PMID42548515
PMCPMC13419223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.