ArticleCHEST pulmonary2024
Sleep Hypoxemia as a Predictor of Mortality in Patients with Sleep Apnea: A Secondary Analysis of the Sleep Heart Health Study.
Article in CHEST pulmonary, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Sleep Circulation Time from Pulse Oximetry and Polysomnography: Predictive Value in Patients with Heart Failure with Reduced Ejection Fraction.Sensors (Basel, Switzerland) · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The Sleep Heart Health Study (SHHS) was a prospective cohort study formulated to explore the risk factors for development of cardiovascular disease in OSA, diagnosed via unaccompanied home sleep apnea test. We used these data to compare the association of the apnea-hypopnea index (AHI) and amount of sleep hypoxemia with the risk of all-cause mortality. Research Question: What is the relationship among hypoxemia, AHI, and mortality in OSA? Study Design and Methods: We compared the association of (1) the AHI, (2) the percentage of sleep time with oxygen saturation < 85% (PERC85), and (3) the duration of sleep (in minutes) with oxygen saturation < 85% (MIN85) with the risk of all-cause mortality in the SHHS. Multivariable logistic regression analyses were used and adjusted for age, sex, BMI, pack-years of smoking, cardiovascular score at baseline, and treatment status. Results: PERC85 was associated with an increased risk of death (OR, 1.03; 95% CI, 1.01-1.05; Interpretation: Our findings indicate that sleep hypoxemia with MIN85 is a better predictor of mortality in OSA than AHI. Monitoring oxygen saturation levels and duration may be important for risk stratification and assessment of treatment adequacy in OSA, although this may be confounded by hypoxemia not related to OSA.
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