ArticleCHEST pulmonary2023
Invasive Cardiopulmonary Exercise Testing Identifies Distinct Physiologic Endotypes in Postacute Sequelae of SARS-CoV-2 Infection.
Article in CHEST pulmonary, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Impaired peripheral oxygen delivery during submaximal exercise in adults with long COVID.Physiological reports · 2026Article
- From fatigue to physiology: Submaximal 2-day cardiopulmonary exercise test and emerging standards in long COVID.Experimental physiology · 2026Article
- Submaximal 2-day cardiopulmonary exercise testing to assess exercise capacity and post-exertional symptom exacerbation in people with long COVID.Experimental physiology · 2026Article
- Chronic Dyspnea and Residual Pulmonary Vascular Sequelae After COVID-19 Pulmonary Embolism: A Retrospective Analysis.Pulmonary circulation · 2025Article
- Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.Physiological reports · 2025Article
- Hemodynamic responses at anaerobic threshold during exercise in preload insufficiency.European journal of clinical investigation · 2025Article
- Evaluating physician concordance in interpretation of tracheobronchomalacia diagnosis and phenotyping using dynamic expiratory chest computed tomography.Scientific reports · 2025Article
- How Is Life After Severe COVID-19?: Functional Cardiopulmonary Outcome and Quality of Life.CHEST pulmonary · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Exercise intolerance and dyspnea on exertion are prominent symptoms in postacute sequelae of COVID-19 (PASC) that significantly impact quality of life, but underlying physiologic contributors are not well understood. Invasive cardiopulmonary exercise testing (iCPET) uses right heart catheterization, arterial access, and standard cardiopulmonary exercise testing to identify pathophysiology in undifferentiated exercise intolerance. Research Question: What are the distinguishing clinical and physiologic features of exercise intolerant PASC and associated physiologic endotypes? Study Design and Methods: We performed a cross-sectional observational study with prospective enrollment of consecutive patients with dyspnea and/or exercise-intolerant PASC who were referred for iCPET > 3 months after SARS-CoV-2 infection. All patients underwent history, physical examination, pulmonary function testing, echocardiogram, laboratory work, and chest imaging. We completed a detailed cardiopulmonary and hemodynamic analysis of 37 patients with iCPET to categorize PASC endotypes. Results: We evaluated 37 patients with PASC and dyspnea on exertion and/or exercise intolerance for a median of 323 days after COVID-19 diagnosis. We compared 12 patients (32.4%) who demonstrated a normal exercise capacity (normal oxygen consumption [ Interpretation: iCPET identified heterogeneous physiologic endotypes in patients with PASC presenting with similar symptoms of exercise intolerance or dyspnea on exertion. Future studies are needed to define associated pathogenesis and target effective therapies based on these physiologic endotypes.
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