Evidence map›Paper›PMID 42548357›Full record

ArticleCHEST pulmonary2024

Respiratory Syncytial Virus Prophylaxis With Palivizumab Is Not Associated With Improved Lung Function in Infants of Very Low Birth Weight at Early School Age.

Ingmar Fortmann, Marie-Theres Dammann, Alexander Humberg, Hannah Kraft, Alexander Herz, Kathrin Hanke, Kirstin Faust, Isabell Ricklefs, Michael Zemlin, Johannes Liese and 8 more

Abstract read
In one paragraph

Article in CHEST pulmonary, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ingmar FortmannDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Marie-Theres DammannDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Alexander HumbergDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Hannah KraftDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Alexander HerzDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Kathrin HankeDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Kirstin FaustDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Isabell RicklefsDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Michael ZemlinDepartment of General Pediatrics and Neonatology, Saarland University, Homburg, Germany.
Johannes LieseDepartment of Pediatrics, University Hospital of Würzburg, Würzburg, Germany.
Geraldine EngelsDepartment of Pediatrics, University Hospital of Würzburg, Würzburg, Germany.
Christoph HärtelDepartment of Pediatrics, University Hospital of Würzburg, Würzburg, Germany.
Carsten Fortmann-GroteDepartment of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Matthias Volkmar KoppDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Folke BrinkmannDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Egbert HertingDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Wolfgang GöpelDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Guido StichtenothDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prematurity and infection with respiratory syncytial virus (RSV) are major risk factors for impaired lung function beyond the neonatal period. Research Question: What are the long-term effects of palivizumab immunoprophylaxis in the first year of life on lung function and frequency of bronchitis episodes in 5- to 6-year-old preterm infants? Study Design and Methods: Preterm infants with a birth weight < 1,500 g (very low-birth weight infants [VLBWIs]) were enrolled in a German Neonatal Network cohort study between 2009 and 2016. Children were examined by a single follow-up team at 5 to 6 years of age. VLBWIs who received at least five doses of palivizumab were compared with children who never received palivizumab. Analyses were stratified by bronchopulmonary dysplasia (BPD) and gestational age. We analyzed FVC, FEV Results: Of 1,986 VLBWIs with follow-up at 5 to 6 years of age, 951 infants (48%) received immunoprophylaxis with palivizumab. Children with BPD (n = 1,019) showed a much lower FEV Interpretation: Palivizumab immunoprophylaxis in VLBWIs is not associated with improved lung function or lower rates of respiratory tract infections in early school-age infants.

Indexed as

immunization of preterm infantslung functionpalivizumab

Identifiers

PMID42548357
PMCPMC13418319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.