Evidence map›Paper›PMID 42548014›Full record

ArticleAdvanced healthcare materials2026

Lysosome-Targeted D-π-A Near-Infrared Photosensitizer With Dual Type-I/Type-II ROS Generation for Hypoxia-Resilient Photodynamic Tumor Therapy.

Yongfei Huang, Li Zhang, Zhefeng Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yongfei HuangSchool of Chemistry and Chemical Engineering, Shanxi Normal University, TaiYuan, China.
Li ZhangSchool of Chemistry and Chemical Engineering, Shanxi Normal University, TaiYuan, China.
Zhefeng FanSchool of Chemistry and Chemical Engineering, Shanxi Normal University, TaiYuan, China.ORCID https://orcid.org/0000-0003-2260-3032

Funding

Analysis and Testing Center of Shanxi Normal UniversityFundamental Research Program of Shanxi Province 202503021211206National Natural Science Foundation of China 22407083
6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a promising minimally invasive antitumor approach, but its clinical efficacy is severely limited by the single Type‑II reaction of conventional photosensitizers (PSs), insufficient subcellular targeting and poor performance in hypoxic tumors. Herein, a lysosome‑targeted D‑-π-‑A near‑infrared PS Lyso‑IsTp was designed and synthesized, with isophorone as acceptor, methoxy‑modified triphenylamine as donor, benzene as π‑bridge and 4‑(2‑chloroethyl)morpholine as targeting moiety. It emitted fluorescence at 750 nm with good photostability and solvent‑dependent properties. Under 660 nm irradiation, Lyso‑IsTp simultaneously produced Type‑I (•OH, O

Indexed as

LysosomesPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesAnimalsApoptosisFemaleHeLa CellsHumansInfrared RaysMiceMice, Inbred BALB CMice, NudePhotosensitizing AgentsReactive Oxygen SpeciesD–π–A conjugatelysosome‐targetingnear‐infrared photosensitizerPDTType‐I/Type‐II ROS

Identifiers

PMID42548014
PMCPMC13542867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.