Trial reportPhysiological reports2026
Intermittent exogenous ketosis increases erythropoietin in healthy adults: A randomized, placebo-controlled study with preliminary sex-specific observations.
Trial report in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Exogenous ketosis may stimulate erythropoietin (EPO), yet its impact on erythropoiesis, iron metabolism, and potential sex-specific responses in humans remains unknown. We investigated these effects in healthy adults using oral β-hydroxybutyrate ketone monoester (KE) to induce intermittent ketosis. Acute EPO responses to a single dose of KE were assessed in 16 healthy adults (pre-post), followed by a 2-week randomized study (KE twice daily vs. placebo). After 2 weeks, EPO levels with intermittent ketosis were approximately 30% higher (95% CI 6, 60), p = 0.01, an effect more evident in females (9.7 IU/L (95% CI 6.0, 13.5) vs. 6.4 IU/L (95% CI 4.0, 8.8), p = 0.008) than in males (10.7 IU/L (7.2, 14.2) vs. 9.6 IU/L (6.3, 12.9), p = 0.46). Ferritin was elevated in females with KE vs. placebo (42 μg/L vs. 16 μg/L, p < 0.001). Hemoglobin and red blood cell count were unaffected at 2 weeks. Over 2 weeks, intermittent exogenous ketosis was associated with a modest increase in erythropoietin levels, with a stronger signal in females. Although hemoglobin and red blood cell count did not change significantly, females showed higher ferritin levels and a trend toward increased hematocrit, suggesting subtle effects on erythropoietic stimulation and iron handling.
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