Evidence map›Paper›PMID 42547894›Full record

ArticleMicrobial cell factories2026

Adaptive laboratory evolution of Saccharomyces cerevisiae enhances butyric acid tolerance and enables co-cultivation with Clostridium tyrobutyricum.

K Oehlenschläger, S Bauschatz, E Schepp, D Holtmann, R Ulber

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In one paragraph

Article in Microbial cell factories, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

K Oehlenschläger *Institute of Bioprocess Engineering, RPTU University Kaiserslautern-Landau, Gottlieb-Daimler-Straße, 67663, Kaiserslautern, Germany.
S Bauschatz *Institute of Bioprocess Engineering, RPTU University Kaiserslautern-Landau, Gottlieb-Daimler-Straße, 67663, Kaiserslautern, Germany.
E ScheppInstitute of Process Engineering in Life Sciences, Karlsruhe Institute of Technology, Fritz-Haber-Weg, 76131, Karlsruhe, Germany.
D HoltmannInstitute of Process Engineering in Life Sciences, Karlsruhe Institute of Technology, Fritz-Haber-Weg, 76131, Karlsruhe, Germany.
R UlberInstitute of Bioprocess Engineering, RPTU University Kaiserslautern-Landau, Gottlieb-Daimler-Straße, 67663, Kaiserslautern, Germany. roland.ulber@mv.rptu.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adaptive laboratory evolution (ALE) was successfully applied to improve the tolerance of Saccharomyces cerevisiae toward butyric acid, enabling its use in co-culture with Clostridium tyrobutyricum for the simultaneous production of ethanol and butyric acid as ester precursors. S. cerevisiae was adapted through serial transfer at progressively increasing butyric acid concentrations up to 20 g L⁻

Indexed as

Butyric AcidClostridium tyrobutyricumSaccharomyces cerevisiaeAdaptation, PhysiologicalCoculture TechniquesEthanolFermentationGlucoseButyric AcidEthanolGlucoseAcid toleranceALEClostridium tyrobutyricumCo-cultureProcess intensificationSaccharomyces cerevisiaeWhole-genome sequencing

Identifiers

PMID42547894
PMCPMC13436328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.