ArticleBMC ophthalmology2026
Longitudinal OCT changes of the peripapillary RNFL after different glaucoma interventions - a comparative study.
Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Impact of Clinical Success Levels on Postoperative RNFL Development After Trabeculectomy.Vision (Basel, Switzerland) · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study's objective was to investigate the development of the peripapillary retinal nerve fiber layer (pRNFL) thickness after Deep Sclerectomy (DS), XEN microstent implantation and Preserflo (PF) microshunt implantation compared to Trabeculectomy (TE).
methodsThis retrospective monocentric study analyzed eyes with primary open-angle glaucoma (POAG) after TE, DS, XEN- or PF-implantation over 2 years. Intraocular pressure (IOP), number of IOP-lowering medications, best-corrected visual acuity (BCVA), and success rates were analyzed. pRNFL was measured by spectral domain optical coherence tomography (SD-OCT).
results462 eyes were analyzed. 108 underwent TE, 183 DS, 90 XEN- and 81 PF-implantation. Mean IOP and mean number of IOP-lowering medications decreased, while BCVA remained stable in all groups. Mean pRNFL significantly decreased in all groups, changing from 64.6 ± 2.0 to 57.8 ± 1.9 μm (-6.8 μm, p < 0.001), 63.6 ± 1.8 to 58.3 ± 2.5 μm (-5.3 μm, p = 0.005), 63.2 ± 2.2 to 60.0 ± 2.1 μm (-3.2 μm, p = 0.008) and 62.1 ± 1.8 to 59.9 ± 1.8 μm (-2.2 μm, p = 0.008) in the TE, DS, XEN and PF groups. Between 1 and 2 years postoperatively, no further statistically significant decline was observed in any group (TE: p = 0.131; DS: p = 0.374; XEN: p = 0.129; PF: p = 0.471).
conclusionsDespite success in reducing IOP and IOP-lowering medications, the pRNFL declines during the first postoperative year, with no further statistically significant decline observed during the second year.
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