ArticleNature neuroscience2026
Probing inter-areal computations with a two-photon holographic mesoscope.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.npj biomedical innovations · 2026Review
- Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing.Neuron · 2026Article
- Computational optimization of two-photon holographic stimulation sitesJournal of neural engineering · 2026Article
- Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces.Neurophotonics · 2026Review
- Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing.Nature neuroscience · 2025Article
- High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing.Nature neuroscience · 2025Article
- Measuring Stimulus Information Transfer Between Neural Populations Through the Communication Subspace.Neural computation · 2025Article
- Feature-specific inhibitory connectivity augments the accuracy of cortical representations.bioRxiv : the preprint server for biology · 2025Article
- Fast photostimulus optimization for holographic control of neural ensemble activitybioRxiv : the preprint server for biology · 2025Article
- Multiphoton Neurophotonics: Recent Advances in Imaging and Manipulating Neuronal Circuits.ACS photonics · 2025Review
- Measuring Stimulus Information Transfer Between Neural Populations through the Communication Subspace.bioRxiv : the preprint server for biology · 2024Article
- Network influence determines the impact of cortical ensembles on stimulus detection.bioRxiv : the preprint server for biology · 2024Article
- Closed-loop experiments and brain machine interfaces with multiphoton microscopy.Neurophotonics · 2024Review
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Authors and funding
5 authors.
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Abstract
Brain computation depends on intricately connected yet highly distributed neural networks. Owing to the absence of the requisite technologies, causally testing fundamental hypotheses on inter-areal processing has remained largely out of reach. Here, we developed a two-photon holographic mesoscope capable of simultaneously reading and writing neural activity patterns with near-single-cell resolution across large regions of the mouse cortex. We demonstrate the precise photoactivation of spatial and temporal sequences of neurons in one or multiple cortical areas while reading out the downstream effects in several other regions. Thus, we have established mesoscale two-photon holographic optogenetics as a platform for mapping functional connectivity and causal interactions across distributed cortical areas with high resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.