ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2026
Dynamic Tear Film Stability Assessed via an Open-View Double-Pass Imaging System.
Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeA novel dynamic optical metric derived from double-pass imaging called the Lacrima Stability Index (LaSI) was evaluated for the objective assessment of tear film stability.
methodsRetinal point spread functions were recorded with an open-view double-pass system at 15.4 Hz with simultaneous pupil tracking. LaSI was defined as the central PSF energy normalised by the total light exiting the eye, and the time-to-90% decay (T90) was introduced as the time for LaSI to decline by 10%.
resultsIn 39 eyes, LaSI traces remained stable in eyes with normal tear film stability but showed progressive decline in eyes with an unstable tear film. Using a 10-s cutoff to distinguish normal from reduced tear film stability subjects, T90 correctly classified 84.6% of eyes and showed a strong correlation with non-invasive break-up time (r = 0.76, p < 0.001). Agreement with the Ocular Surface Disease Index-6 scores was comparable for T90 and the non-invasive tear break-up time, although differences reflected the known dissociation between signs and symptoms.
conclusionsThese findings suggest that LaSI provides a sensitive, time-resolved metric of tear film dynamics, with T90 serving as a clinically interpretable marker of tear film stability.
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