Evidence map›Paper›PMID 42547687›Full record

ArticleHuman cell2026

HIPK2 exhibits context dependent dualistic effects and combinatorial inhibition of HIPK2-NLK-MAPK11 axis manifests synergism against gastric cancer.

Aathithya Rangarajan, Thirumoorthi Natarajan, Sujatha Lakshminarayanan, Shirley SunderSingh, Jayavelu Subramani, Priya Ramanathan, Ramakrishnan Ayloor Seshadri, Gopal Gopisetty

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aathithya RangarajanDepartment of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.
Thirumoorthi NatarajanDepartment of Medical Gastroenterology and Endoscopy, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.
Sujatha LakshminarayananDepartment of Medical Gastroenterology and Endoscopy, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.
Shirley SunderSinghDepartment of Oncopathology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.
Jayavelu SubramaniDepartment of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.
Priya RamanathanDepartment of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.
Ramakrishnan Ayloor SeshadriDepartment of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.
Gopal GopisettyDepartment of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India. g.gopal@cancerinstitutewia.org.ORCID http://orcid.org/0000-0002-7869-4343

Funding

Department of Science and Technology's Science and Engineering Research Board (DST-SERB) CRG/2020/000877
6 · The paper itself

Abstract

Homeodomain-interacting protein kinase 2 (HIPK2) can function either as a tumour suppressor or promoter in cancer. Understanding key features of HIPK2 context dependent effects in cancer could lead to novel therapeutic strategies. Our investigation of HIPK2 expression in gastric cancer (GC) showed it to be down regulated.HIPK2 manifested context dependent anti- and pro-tumorigenic effects as demonstrated in GC cell lines SNU638 and NUGC-3 (β-Catenin

Indexed as

Carrier ProteinsGene ExpressionIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesStomach NeoplasmsCell Line, TumorDown-RegulationHumansMitogen-Activated Protein Kinase Kinase Kinase 11Proto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesCarrier ProteinsHIPK2 protein, humanIntracellular Signaling Peptides and ProteinsMitogen-Activated Protein Kinase Kinase Kinase 11MTOR protein, humanProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesGastric cancerHIPK2Kinase inhibitorsMAPK11NLKTumour suppressor kinases

Identifiers

PMID42547687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.