ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Gestational age-specific metabolic biomarkers for early prediction of bronchopulmonary dysplasia following standardized enteral feeding.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEarly prediction of Bronchopulmonary dysplasia (BPD) remains challenging. Utilizing the NRN 2019 definition and a standardized feeding protocol, this study aimed to identify gestational age (GA)-specific metabolic signatures to optimize early prediction.
methodsThis retrospective study enrolled 455 preterm infants (GA < 32 weeks). Dried blood spots collected at ~14 days postnatal age following standardized nutritional management were analyzed for 83 metabolites via LC-MS/MS to construct GA-stratified predictive models.
resultsDistinct GA-specific metabolic signatures involving specific amino acid and acylcarnitine alterations were identified. Incorporating these biomarkers significantly improved predictive models compared to baseline clinical models: the AUC increased from 0.765 to 0.852 in the GA < 28 weeks subgroup, and from 0.629 to 0.707 in the GA 28-31
conclusionsPost-standardized feeding metabolic profiling at 2 weeks captures distinct GA-specific alterations. Integrating these biomarkers with NRN 2019 criteria significantly enhances early BPD prediction, offering clinical utility for targeted risk stratification.
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