Evidence map›Paper›PMID 42546775›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2026

The ubiquitin-activating enzyme inhibitor TAK-243 activates store-operated Ca

Marie Perrier, J Cory Benson, Marie-Odile Fauvarque, Mohamed Trebak, Alexandre Bouron

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marie PerrierUniversité Grenoble Alpes, CNRS, CEA, Inserm, IRIG, BGE UA13, F-38000, Grenoble, France.
J Cory BensonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Marie-Odile FauvarqueUniversité Grenoble Alpes, CNRS, CEA, Inserm, IRIG, BGE UA13, F-38000, Grenoble, France.
Mohamed TrebakDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alexandre BouronUniversité Grenoble Alpes, CNRS, CEA, Inserm, IRIG, BGE UA13, F-38000, Grenoble, France. Electronic address: alexandre.bouron@cea.fr.

Funding

Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
NHLBI NIH HHS R35 HL150778
6 · The paper itself

Abstract

TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1, impairs the ubiquitination of proteins. We investigated its effects on the intracellular Ca

Indexed as

CalciumCalcium ChannelsEndoplasmic ReticulumMitochondriaProstatic NeoplasmsCalcium SignalingCell Line, TumorHumansMaleCalciumCalcium ChannelsCalcium imagingCalcium intracellular releaseCalcium release-activated calcium channel protein 1 (ORAI1)Calcium transportProstate cancerUbiquitination

Identifiers

PMID42546775
PMCPMC13624583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.