Bicaudal D acts as a sensor to enable dynein-kinesin co-dependence.

Hailong Lu, M Yusuf Ali, Jill E Macfarlane, Patricia M Fagnant, Kathleen M Trybus

Abstract read

In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hailong LuDepartment of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA.

M Yusuf AliDepartment of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA. Electronic address: yusuf.ali@med.uvm.edu.

Jill E MacfarlaneDepartment of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA.

Patricia M FagnantDepartment of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA.

Kathleen M TrybusDepartment of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA. Electronic address: kathleen.trybus@uvm.edu.

Funding

Molecular Mechanisms of Motility Deduced from in Vitro Reconstituted Microtubule- and Actin-Based Motor ComplexesR35GM136288 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KATHLEEN M TRYBUS · 2020 to 2026

$2.5M

Mechanism by Which the Bicaudal D2-Nuclear Pore Protein 358 Interaction Activates Microtubule-based Cargo TransportR03NS126811 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ALI, M YUSUF · 2023 to 2023

$156k

NIGMS NIH HHS R35 GM136288NINDS NIH HHS R03 NS126811

6 · The paper itself

Abstract

Cellular cargoes bind both the minus-end-directed motor dynein and the plus-end-directed motor kinesin, enabling bidirectional motion along microtubules. The molecular mechanism to explain why knocking down one motor abolishes motion in both directions, called the "paradox of co-dependence," remains enigmatic. Here, we use a model system consisting of dynein/dynactin and kinesin bound to the activating adaptor BicD to investigate this phenomenon. We demonstrate that run lengths are significantly increased when a full-length motor and a tail construct of the opposing motor are simultaneously bound to the same BicD, caused by an enhanced recruitment of two active motors to the complex. Notably, a registry-shifted point mutant of BicD (BicD

Indexed as

Drosophila ProteinsDyneinsKinesinsAnimalsDynactin ComplexMicrotubule-Associated ProteinsMicrotubulesProtein BindingBicD protein, DrosophilaDrosophila ProteinsDynactin ComplexDyneinsKinesinsMicrotubule-Associated Proteinsadaptor proteinBicDdyneinkinesinmicrotubule

Identifiers

PMID42546704

DOI10.1016/j.cub.2026.07.018

PMCPMC13480309

What OpenQuestion holds

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Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.