Evidence map›Paper›PMID 42546688›Full record

ArticleCell2026

Co-option of retrotransposons promotes antibody diversification.

Max C Lauring, Ming Yang, Aditya Sarode, Jianhua Wang, Zixin Ni, Kristen A Froehlich, Wanwei Zhang, Shudipto Wahed, Sisi Zheng, Stephen P Goff and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Max C LauringDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Ming YangDivision of Life Science, Department of Chemical and Biological Engineering and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
Aditya SarodeDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jianhua WangDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Zixin NiDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Kristen A FroehlichDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Wanwei ZhangDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Shudipto WahedDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Sisi ZhengDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.
Stephen P GoffDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Jiguang WangDivision of Life Science, Department of Chemical and Biological Engineering and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China. Electronic address: jgwang@ust.hk.
Uttiya BasuDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: ub2121@cumc.columbia.edu.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic HypermutationR01AI099195 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2012 to 2026
$9.8M
Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Long noncoding RNA expressing genomic element that control antibody diversification and chromosomal integrity in B cellsR01AI134988 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2018 to 2026
$4.7M
The role of N6-methyladenosine RNA modification in programmed and aberrant DNA mutagenesis in B cellsR01AI143897 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2020 to 2026
$3.4M
RNA associated mechanisms for antigen receptor gene diversification during immature B cell developmentR01AI178892 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2024 to 2026
$1.7M
RNA Decay of LINE-1 Retrotransposons as a New Mechanism to Maintain B Cell Genome IntegrityF30AI179182 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Max Chen Lauring · 2024 to 2026
$159k
NCI NIH HHS P30 CA013696NIAID NIH HHS F30 AI179182NIAID NIH HHS R01 AI099195NIAID NIH HHS R01 AI134988NIAID NIH HHS R01 AI143897NIAID NIH HHS R01 AI178892NIGMS NIH HHS T32 GM145440
6 · The paper itself

Abstract

Activation-induced cytidine deaminase (AID) accomplishes somatic hypermutation (SHM) of V

Indexed as

Antibody DiversityLong Interspersed Nucleotide ElementsAICDA (Activation-Induced Cytidine Deaminase)AnimalsB-LymphocytesCytidine DeaminaseGerminal CenterHumansMiceMice, KnockoutRetroelementsSomatic Hypermutation, ImmunoglobulinAICDA (Activation-Induced Cytidine Deaminase)Cytidine DeaminaseRetroelementsAIDantisense transcriptiongerminal centerHUSH complexL1LINE-1retrotransposonssomatic hypermutationV(H)(D)J(H) recombination

Identifiers

PMID42546688
PMCPMC13656868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.