ArticleJournal of the American Chemical Society2026
Backbone Hydrogen Bonding as a Determinant of Condensate Material States.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Condensate material states ranging from liquid droplets to gels have direct functional consequences, but their molecular determinants, especially for gels, are poorly understood. Here we combined optical microscopy, NMR spectroscopy, and molecular dynamics (MD) simulations to test the hypothesis that backbone hydrogen bonding is a determinant for the material states of XYssYX tetrapeptides. IAssAI forms droplets, but AIssIA forms gels; MD simulations show a higher level of hydrogen bonds in AIssIA condensates than in IAssAI condensates. The addition of a low-hydrogen-bonding peptide, AAssAA, converts AIssIA gels into droplets. The same effect is achieved by increasing the number of terminal A added to AIssIA and by methylating the backbone amides of AIssIA to block hydrogen bonding. 1H-1H nuclear Overhauser effect spectroscopy coupled with MD simulations reveals strong, backbone hydrogen bonding-buttressed molecular networks in AIssIA gels. These results demonstrate that, in addition to side chain-side chain interaction strength, backbone hydrogen bonding, by promoting directional growth, is a determinant of condensate material states.
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