Evidence map›Paper›PMID 42546184›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Bladder mucosal afferents detect UTI and aid pathogen clearance.

Cindy Tay, Harman Sharma, Stewart Ramsay, Georgia Bourlotos, Sarah K Manning, Natalie E Stevens, Sophie J Miller, Geraint B Rogers, David J Lynn, Feargal J Ryan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cindy TayCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0009-0001-7113-9179
Harman SharmaCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Stewart RamsayLifelong Health, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
Georgia BourlotosCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Sarah K ManningCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Natalie E StevensCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0000-0002-7637-8013
Sophie J MillerCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0009-0003-3889-7941
Geraint B RogersCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
David J LynnCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Feargal J RyanCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Andrea M HarringtonVisceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.ORCID 0000-0002-1562-4137
Vladimir ZagorodnyukCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0000-0001-6418-7482
Steven L TaylorCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.
Luke GrundyCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0000-0002-3900-7141

Funding

Department of Education and Training | Australian Research Council (ARC) DP260100487DHAC | National Health and Medical Research Council (NHMRC) 2008625DHAC | National Health and Medical Research Council (NHMRC) 2017404Flinders Foundation Health Seed Grant
6 · The paper itself

Abstract

The bladder is innervated by a complex network of sensory neurons that detect and transmit mechanical and chemical signals to the central nervous system, regulating both urine storage and voiding, and mediating sensations of bladder fullness and pain. While stretch-sensitive afferents within the bladder wall are known to monitor bladder tension, the contribution of stretch-insensitive afferents that reside within the bladder mucosa to bladder sensation and function remains unclear. Here, we establish a mouse model of selective bladder mucosal afferent denervation using intravesical instillation of resiniferatoxin to define the functional roles of these fibers in health and disease. We assessed the impact of mucosal denervation on sensory nerve activity and bladder function in healthy mice and in a model of urinary tract infection (UTI) induced by acute bacterial challenge with uropathogenic

Indexed as

Escherichia coli InfectionsMucous MembraneNeurons, AfferentUrinary BladderUrinary Tract InfectionsAnimalsDisease Models, AnimalDiterpenesFemaleMiceMice, Inbred C57BLUropathogenic Escherichia coliDiterpenesresiniferatoxinbladder afferentcystitisinfectionpainurinary tract infection

Identifiers

PMID42546184
PMCPMC13462357

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.