Evidence map›Paper›PMID 42546182›Full record

ArticleThe Journal of physiology2026

On the adaptive significance of group III/IV muscle afferent feedback for the cardiovascular response during sustained locomotion in humans.

D Iannetta, F G Laginestra, T S Thurston, R H Jenkinson, J Chang, H-Y Wan, R M Broxterman, J C Weavil, M Amann

Abstract read
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

D IannettaDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0001-6914-174X
F G LaginestraDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-4767-7249
T S ThurstonDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, USA.
R H JenkinsonDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, USA.
J ChangDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, USA.
H-Y WanDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, USA.
R M BroxtermanGeriatric Research, Education, and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-7388-2214
J C WeavilGeriatric Research, Education, and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah, USA.
M AmannDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-4012-8880

Funding

Autonomic Dysfunction in Patients with HFpEFR01HL162856 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2023 to 2026
$2.7M
Cardiovascular and neuromuscular issues in chronic painR01HL170007 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2024 to 2026
$2.3M
NHLBI NIH HHS HL-116579NHLBI NIH HHS HL-162856NHLBI NIH HHS R01 HL162856NHLBI NIH HHS R01 HL170007RRD VA I01 RX003343U.S. Veterans Affairs Rehabilitation Research and Development E3343-R
6 · The paper itself

Abstract

While the cardiovascular consequences of group III/IV muscle afferent feedback have been studied during short-duration exercise, its role during sustained (> 5 min) locomotion remains unknown. Thirteen healthy individuals (4f/9m) completed two 20-min cycling bouts at ∼50% (moderate) and ∼75% (heavy) of

Indexed as

Feedback, PhysiologicalLocomotionMuscle, SkeletalAdaptation, PhysiologicalAdultAfferent PathwaysBlood PressureCardiac OutputExerciseFemaleFentanylHumansLegMaleRegional Blood FlowYoung AdultFentanylarterial blood pressurecardiac outputexercise pressor reflexleg blood flowoxygen delivery

Identifiers

PMID42546182
PMCPMC13532924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.