Evidence map›Paper›PMID 42546101›Full record

Observational studyCirculation2026

Left Ventricular Hypertrabeculation and Prognosis in Dilated Cardiomyopathy.

Nerea Mora-Ayestarán, Noemi Ramos-Lopez, Juan Pablo Ochoa, Amaia Yuan Ibargoyen, Eduard Claver-Garrido, Cristina Gómez-González, Ahmad S Amin, María Gallego-Delgado, Guillem Casas-Masnou, Marina Navarro-Peñalver and 31 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Nerea Mora-Ayestarán *Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto de Investigación Sanitaria Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain (N.M.-A., N.R.-L., J.G.M., P.G.-P.).ORCID 0000-0002-2127-5287
Noemi Ramos-Lopez *Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto de Investigación Sanitaria Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain (N.M.-A., N.R.-L., J.G.M., P.G.-P.).ORCID 0000-0002-0868-1707
Juan Pablo OchoaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (N.R.-L., J.P.O., A.G.-Á., P.G.-P.).ORCID 0000-0002-7966-0313
Amaia Yuan IbargoyenDepartment of Cardiology, Área del Corazón, Hospital Universitario de Navarra, Pamplona, Spain (A.Y.I., M.S., G.L.-L., M.T.B.-E.).ORCID 0009-0000-4484-7842
Eduard Claver-GarridoDepartment of Cardiology, Hospital Universitari de Bellvitge (E.C.-G., C.D.-L., A.D.), l'Hospitalet de Llobregat, Spain.
Cristina Gómez-GonzálezDepartment of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain (C.G.-G., E.R.G., M.A.E.-C.).
Ahmad S AminDepartment of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands (A.S.A., E.P., C.R.B.).ORCID 0000-0002-1600-7907
María Gallego-DelgadoCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0003-0726-9646
Guillem Casas-MasnouCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0001-7122-320X
Marina Navarro-PeñalverCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0002-6254-6039
Jose María Larrañaga-MoreiraUnidad de Cardiopatías Familiares, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña, Spain (J.M.L.-M., R.B.-V.).ORCID 0000-0003-4642-4098
José Manuel García-PinillaCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).
Francisco J Bermudez-JimenezServicio de Cardiología, Hospital Universitario Virgen de las Nieves, Granada, Spain (F.J.B.-J.).ORCID 0000-0003-0325-7349
Maria Victoria Mogollón-JiménezDepartment of Cardiology, Complejo Hospitalario Universitario de Cáceres, Spain (M.V.M.-J.).ORCID 0000-0001-6014-0206
Gonzalo Cabezón-VillalbaCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0002-6945-1446
Antoni Bayes-GenisCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0002-3044-197X
Vicente Climent-PayáHeart Failure and Inherited Cardiac Diseases Unit, Cardiology Department, Dr Balmis General University Hospital, Alicante, Spain (V.C.-P.).ORCID 0000-0001-7362-1922
Rafael Salguero-BodesCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0003-1038-9710
Ana García-ÁlvarezCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (N.R.-L., J.P.O., A.G.-Á., P.G.-P.).ORCID 0000-0002-1718-2424
María BrionCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0001-7463-2148
Ramon BrugadaCardiology, Cardiac Genetics Clinical Unit, Hospital Universitari Josep Trueta, Hospital Santa Caterina, Girona, Spain (R.B.).ORCID 0000-0001-6607-3032
Esther ZorioCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0003-3608-4210
Tomas Ripoll-VeraUnidad de Cardiopatías Familiares, Hospital Universitario Son Llatzer, Palma de Mallorca, Spain (T.R.-V.).ORCID 0000-0001-9222-325X
María Luisa Peña-PeñaServicio de Cardiología, Unidad de Cardiopatías Familiares, Hospital Universitario Virgen del Rocío, Sevilla, Spain (M.L.P.-P.).ORCID 0000-0002-4861-0831
Ana RoyuelaBiostatistics Unit, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERESP, ISCIII, Madrid, Spain (A.R.).ORCID 0000-0003-1665-081X
Miriam SánchezDepartment of Cardiology, Área del Corazón, Hospital Universitario de Navarra, Pamplona, Spain (A.Y.I., M.S., G.L.-L., M.T.B.-E.).ORCID 0009-0009-8573-9851
Carles Diez-LopezDepartment of Cardiology, Hospital Universitari de Bellvitge (E.C.-G., C.D.-L., A.D.), l'Hospitalet de Llobregat, Spain.ORCID 0000-0002-3734-4777
Elena Rodríguez GonzálezDepartment of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain (C.G.-G., E.R.G., M.A.E.-C.).ORCID 0000-0002-3154-9034
Edwin PoelDepartment of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands (A.S.A., E.P., C.R.B.).ORCID 0000-0003-0279-5129
Eduardo VillacortaCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0003-0486-1740
Javier Limeres-FreireCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0003-3644-9494
María Sabater-MolinaCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0003-2043-356X
Roberto Barriales-VillaCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).ORCID 0000-0002-6721-3487
Gemma Lacuey-LecumberriDepartment of Cardiology, Área del Corazón, Hospital Universitario de Navarra, Pamplona, Spain (A.Y.I., M.S., G.L.-L., M.T.B.-E.).ORCID 0000-0003-1352-1748
Andrea Di MarcoDepartment of Cardiology, Hospital Universitari de Bellvitge (E.C.-G., C.D.-L., A.D.), l'Hospitalet de Llobregat, Spain.ORCID 0000-0001-8322-8112
María Angeles Espinosa-CastroDepartment of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain (C.G.-G., E.R.G., M.A.E.-C.).ORCID 0000-0003-1914-8104
Connie R BezzinaDepartment of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands (A.S.A., E.P., C.R.B.).ORCID 0000-0002-0633-3514
José F Rodríguez-PalomaresCIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (C.G.-G., M.G.-D., G.C.-M., M.N.-P., J.M.G.-P., G.C.-V., A.B.-G., R.S.-B., A.G.-Á., M.B., E.Z., E.R.G., E.V., J.L.-F., M.S.-M., R.B.-V., A.D., M.A.E.-C., J.F.R.-P., J.G.M., P.G.-P.).
María Teresa Basurte-ElorzDepartment of Cardiology, Área del Corazón, Hospital Universitario de Navarra, Pamplona, Spain (A.Y.I., M.S., G.L.-L., M.T.B.-E.).ORCID 0000-0002-8689-0301
Jesus G Mirelis *Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto de Investigación Sanitaria Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain (N.M.-A., N.R.-L., J.G.M., P.G.-P.).
Pablo Garcia-Pavia *Department of Cardiology, Hospital Universitario Puerta de Hierro, Instituto de Investigación Sanitaria Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain (N.M.-A., N.R.-L., J.G.M., P.G.-P.).ORCID 0000-0002-5470-2257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft ventricular (LV) hypertrabeculation, formerly termed LV noncompaction, is a heterogeneous myocardial entity linked to adverse cardiovascular outcomes. This study evaluated embolic risk in patients with dilated cardiomyopathy (DCM) according to the presence of hypertrabeculation and examined its prevalence and prognostic relevance across DCM genotypes.

methodsClinical data from 1160 patients with DCM evaluated by cardiac magnetic resonance imaging and genetic testing (n=997 [86%]) were collected from 22 international centers. End points included embolic events, advanced heart failure events, and major ventricular arrhythmias.

resultsLV hypertrabeculation was identified in 354 patients (30.5%) by fractal analysis and in 343 (29.7%) according to Petersen criteria, with good concordance. After a median follow-up of 5.1 years (interquartile range, 2.8-7.4), embolic events occurred in 37 patients (3.2%), advanced heart failure in 62 (5.3%), and major ventricular arrhythmias in 136 (11.7%). Hypertrabeculation was not associated with increased embolic risk (hazard ratio, 1.5 [95% CI, 0.75-3.00]), even among patients in sinus rhythm with LV ejection fraction ≤40% (hazard ratio, 1.89 [95% CI, 0.7-5.5]). In contrast, atrial fibrillation and reduced LV ejection fraction were associated with embolic events (both

conclusionsAlthough LV hypertrabeculation is common in DCM, it is not associated with worse outcomes and should not prompt differential clinical management. The embolic risk in patients with DCM and hypertrabeculation is low, including in those with reduced LV ejection fraction without atrial fibrillation, and does not support prophylactic anticoagulation in these patients.

Indexed as

Cardiomyopathy, DilatedAdultArrhythmias, CardiacEmbolismFemaleHeart FailureHumansMaleMiddle AgedPrognosisRisk Factorscardiomyopathydilatedembolismgenesprognosis

Identifiers

PMID42546101
PMCPMC13432967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.