Evidence map›Paper›PMID 42545947›Full record

ArticleKidney & blood pressure research2026

Nephrogenic Diabetes Insipidus Presenting with Hypokalemic Paralysis in an Adolescent with Primary Sjögren's Syndrome: A Case Report.

Qiaofang Ke, Xinguang Ma, Zhiyong Xu, Gaoyan Dai, Feifei Li, Tenghui Wu, Yingqian Li, Hui Wu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney & blood pressure research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Qiaofang KeDepartment of Endocrinology, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Xianju, China.
Xinguang MaDepartment of Ultrasound, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Xianju, China.
Zhiyong XuDepartment of Endocrinology, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Xianju, China.
Gaoyan DaiDepartment of Endocrinology, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Xianju, China.
Feifei LiDepartment of Endocrinology, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Xianju, China.
Tenghui WuDepartment of Endocrinology, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Xianju, China.
Yingqian LiDepartment of Endocrinology, Xianju People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College, Xianju, China.
Hui WuKey Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, China, latinboy@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiabetes insipidus is a rare disorder characterized by polyuria, polydipsia, and dilute urine. Nephrogenic diabetes insipidus (NDI) secondary to distal renal tubular acidosis (dRTA) in primary Sjögren's syndrome (pSS) is exceedingly rare in children. CASE PRESENTATION: A 16-year-old girl presented with hypokalemic paralysis (potassium 1.89 mmol/L), polyuria (>5 L/day), and growth retardation (height 141 cm, <3rd percentile). Laboratory studies revealed dRTA with secondary NDI. Autoimmune workup confirmed pSS. A systematic literature review identified only 5 similar pediatric cases. Initial management with hydrochlorothiazide exacerbated hypokalemia and precipitated hypochloremic metabolic alkalosis. Switching to amiloride combined with glucocorticoids and potassium supplementation normalized electrolytes, reduced urine output to 1.5 L/day, and resulted in catch-up growth at the 6-month follow-up.

conclusionThis case highlights the pathophysiologic cascade of pSS-related dRTA causing secondary NDI and underscores the importance of early recognition and tailored diuretic selection in adolescents.

Indexed as

Diabetes Insipidus, NephrogenicHypokalemiaParalysisSjogren's SyndromeAcidosis, Renal TubularAdolescentFemaleHumansDistal renal tubular acidosisHypokalemic paralysisNephrogenic diabetes insipidusSjögren’s syndrome

Identifiers

PMID42545947
PMCPMC13585412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.