Evidence map›Paper›PMID 42545915›Full record

ArticleFetal diagnosis and therapy2026

Perinatal Mood and Anxiety in Women Undergoing Open Maternal-Fetal Surgery for Myelomeningocele Closure.

Alexandria Budney, Juliana S Gebb, Shelly Soni, Nahla Khalek, Julie S Moldenhauer, Joanna C M Cole, Gregory G Heuer, N Scott Adzick, Christina Paidas Teefey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fetal diagnosis and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandria BudneyDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Juliana S GebbDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Shelly SoniDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Nahla KhalekDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Julie S MoldenhauerDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Joanna C M ColeDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Gregory G HeuerDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
N Scott AdzickDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Christina Paidas TeefeyDivision of Pediatric General, Thoracic and Fetal Surgery, Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, christina.paidas@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPregnant people carrying fetuses with congenital anomalies are at increased risk for perinatal mood and anxiety disorders (PMADs). Limited data exist regarding the impact of maternal-fetal surgery on maternal mental health. This study aimed to evaluate PMAD symptoms in pregnant people who opted for open maternal-fetal surgery (OMFS) for spina bifida (fMMC) closure.

methodsThis was a retrospective cohort study of patients who underwent OMFS for fMMC closure at a level III fetal center. The Postpartum Depression Screening Scale (PDSS) and Impact of Event Scale-Revised (IES-R) were administered at initial evaluation and 1 day post-birth. Demographics, perioperative factors, surgical and delivery outcomes, and type of psychosocial support interactions were collected.

resultsOf 171 pregnant people who underwent OMFS, 91 (50.8%) screened positive for depressive symptoms and 27 (15.1%) for anxiety/traumatic stress at the initial evaluation, prior to OMFS. After delivery, 45 (25.1%) screened positive for depressive symptoms and 2 (0.01%) for anxiety/traumatic stress symptoms. There was a statistically significant decrease in positive screen rates in the postpartum period for depressive and anxiety/traumatic stress (p < 0.001).

conclusionsWomen undergoing OMFS for fMMC closure are at a high risk for PMAD symptoms in the perinatal period. Routine mental health screening in pregnancy and integrated psychosocial support are essential in caring for this unique population.

Indexed as

AnxietyDepressionFetal surgeryMyelomeningoceleOpen maternal-fetal surgeryPerinatal mood and anxiety disordersSpina bifida

Identifiers

PMID42545915
PMCPMC13619127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.