Observational studyCritical care explorations2026
Safety and Feasibility of Bedside Electrical Impedance Tomography With Hypertonic Saline Contrast for Assessing Pulmonary Perfusion in Mechanically Ventilated Children With Acute Respiratory Distress Syndrome: A Pilot Study.
Observational study in Critical care explorations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
importanceElectrical impedance tomography (EIT) offers a noninvasive, radiation-free imaging alternative, but its perfusion evaluation capability in children is understudied. Hypertonic saline-enhanced EIT may address this gap, enabling real-time guidance for individualized respiratory support.
objectivesThis study aims to systematically assess the safety and efficacy of hypertonic saline-enhanced bedside EIT in evaluating pulmonary perfusion in pediatric patients with acute respiratory distress syndrome (ARDS).
designSingle-center prospective observational study. SETTING AND
participantsPediatric ARDS patients undergoing invasive mechanical ventilation were enrolled at the PICU of the Capital Center for Children's Health, Capital Medical University, China, from December 29, 2024, to August 7, 2025. MAIN OUTCOMES AND MEASURES: Each participant received a central venous bolus of 0.2 mL/kg (up to a maximum of 10 mL) of a 10% hypertonic saline. EIT data were collected from 2 minutes before the injection to 1-2 minutes following it. Key parameters, including dead space ventilation fraction, intrapulmonary shunt fraction, and ventilation/perfusion (V/Q) matching percentage, were analyzed to evaluate lung pathophysiology and inform therapeutic strategies. The study monitored eight patients (four males, four females; ages ranging from 4 mo to 11 yr).
resultsAll procedures were well-tolerated, with no adverse events, including hypernatremia. In five patients who also underwent contrast-enhanced CT, EIT findings were consistent with CT results. Seven patients demonstrated matched V/Q ratios (74.97-80.39%), while one patient with pulmonary embolism exhibited increased dead space ventilation (37.03%) and decreased V/Q matching (60.71%). CONCLUSIONS AND RELEVANCE: Hypertonic saline-enhanced EIT is a safe, effective, and feasible bedside method for evaluating pulmonary perfusion in mechanically ventilated children with ARDS. These findings implied potential associations with the CT outcomes, indicating its significant potential for guiding targeted respiratory management. Although promising, these results stem from a small sample size, necessitating further validation in larger studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.