Evidence map›Paper›PMID 42545841›Full record

ArticleChemistry, an Asian journal2026

Diversity-Oriented Synthesis of Thiophenes Via Switchable Annulation of Ninhydrin-Derived MBH Esters With α-Enolic Dithioesters.

Si Zhao, Sifeng Li, Peng Li, Bin Cheng, Yun Luo, Ying Zhang, Kang Zhou, Taimin Wang, Hongbin Zhai, Shaobin Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Si ZhaoSchool of Pharmacy, Zunyi Medical University, Zunyi, China.
Sifeng LiSchool of Food and Drug-Institute of Critical Materials for Integrated Circuits, Shenzhen Polytechnic University, Shenzhen, China.ORCID https://orcid.org/0000-0002-5302-1599
Peng LiSchool of Food and Drug-Institute of Critical Materials for Integrated Circuits, Shenzhen Polytechnic University, Shenzhen, China.
Bin ChengSchool of Pharmacy, Zunyi Medical University, Zunyi, China.ORCID https://orcid.org/0000-0002-8276-6653
Yun LuoSchool of Pharmacy, Zunyi Medical University, Zunyi, China.
Ying ZhangSchool of Food and Drug-Institute of Critical Materials for Integrated Circuits, Shenzhen Polytechnic University, Shenzhen, China.
Kang ZhouSchool of Food and Drug-Institute of Critical Materials for Integrated Circuits, Shenzhen Polytechnic University, Shenzhen, China.
Taimin WangSchool of Pharmacy, Zunyi Medical University, Zunyi, China.
Hongbin ZhaiState Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, China.
Shaobin FuSchool of Pharmacy, Zunyi Medical University, Zunyi, China.

Funding

Research Projects of Department of Education of Guangdong Province 2025CJPT003Scientific Research Startup Fund for Shenzhen High-Caliber Personnel of SZPU 6023330007KShenzhen Polytechnic University Research Fund 6026310047K
6 · The paper itself

Abstract

We report a diversity-oriented synthesis of thiophene derivatives via a switchable annulation of ninhydrin-derived MBH esters with α-enolic dithioesters. By modulating the leaving groups of MBH esters (acetoxy vs. tert-butoxycarbonyloxy) and optimizing base-solvent combinations, three distinct thiophene scaffolds are selectively obtained in moderate to good yields. The regioselective synthesis is enabled by switchable S- or C-allylation pathways and subsequent divergent cyclization, providing a practical platform for accessing structurally diverse thiophene derivatives.

Indexed as

divergent cyclizationdiversity‐oriented synthesisninhydrin‐derived MBH estersthiophenesα‐enolic dithioesters

Identifiers

PMID42545841
PMCPMC13431351

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.