Evidence map›Paper›PMID 42545636›Full record

ArticleCEN case reports2026

Maintenance of clinical remission with cyclosporine after discontinuation of prednisolone in a patient with tubulointerstitial nephritis with IgM-positive plasma cells.

Kazuki Yamada, Shiori Nakao, Minori Ikeda, Reina Suetsugu-Ishizawa, Nozomi Hayashi, Hirofumi Sakuma, Motoki Matsuki, Naoki Takahashi, Masayuki Iwano, Tadashi Toyama and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kazuki Yamada *Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.
Shiori Nakao *Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.
Minori IkedaDivision of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.
Reina Suetsugu-IshizawaDivision of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.
Nozomi HayashiDivision of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.
Hirofumi SakumaDivision of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.
Motoki MatsukiDivision of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan.
Naoki TakahashiDepartment of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Masayuki IwanoDepartment of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Tadashi ToyamaDepartment of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yayoi OgawaDepartment of Pathology, Sapporo Tokushukai Hospital, Sapporo, Japan.
Naoki NakagawaDivision of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Japan. naka-nao@asahikawa-med.ac.jp.ORCID 0000-0002-5398-3667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an inflammatory disease characterized by the infiltration of IgM and CD138 dual-positive plasma cells into the renal interstitium. Steroid treatment is effective for many cases of IgMPC-TIN. However, the optimal dose and duration of steroid therapy remain poorly understood. In the present case, IgMPC-TIN was diagnosed in a 36-year-old woman with femoral head osteonecrosis. After administration of prednisolone (PSL, 20 mg/day), several markers of disease activity gradually decreased. The PSL dose was tapered to 5 mg/day for one year without TIN recurrence. To avoid exacerbation of bone lesions due to prolonged administration of PSL, cyclosporine was added to PSL. Combination treatment with 5 mg/day PSL and 100-125 mg/day cyclosporine stabilized the TIN. The patient remained stable without recurrence after further reduction and discontinuation of PSL. This case provides original evidence regarding the optimal treatment regimen for patients with IgMPC-TIN who are unsuitable for prolonged PSL administration.

Indexed as

CyclosporineNephritis, InterstitialPlasma CellsPrednisoloneAdultDrug Therapy, CombinationFemaleHumansImmunoglobulin MImmunosuppressive AgentsRemission InductionTreatment OutcomeCyclosporineImmunoglobulin MImmunosuppressive AgentsPrednisoloneCyclosporinePrednisoloneTubulointerstitial nephritis

Identifiers

PMID42545636
PMCPMC13433678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.