ArticleStem cell reviews and reports2026
Natural Killer Cell Immunotherapy After Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia Patients: Phase I Clinical Trial.
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Abstract
backgroundImmunotherapy offers a promising approach to prevent relapse and transplant complications. Natural killer (NK) cells play a crucial role in the immune system's initial defense against infections and malignant cells. Activation of NK cells with interleukin-15 enhances anti-leukemic immune responses. We conducted this clinical trial to evaluate the safety and efficacy of CD56 + cell infusion in increasing survival and reducing relapse in patients with acute myeloid leukemia.
methodsThree escalating doses of 1 × 10
resultsThe CD56 + cells infusion was safe and not associated with any complications. While survival rates were not statistically different between the intervention and control groups, a trend toward improved survival was observed in the intervention group. Patients with complete remission showed a higher percentage of NK cells on day + 40 than patients who experienced graft rejection, relapse, or death.
conclusionsIn this study, we introduce a feasible method for activating CD56 + cells. Although the survival rates of patients in the intervention and control groups did not differ statistically, this study showed that a higher percentage of NK cells on day + 40 is associated with better survival and fewer complications following transplantation.
trial registrationThis study was registered at the Iranian Registry of Clinical Trials under code IRCT20230801058996N2 on 2023-09-10.
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