Evidence map›Paper›PMID 42545538›Full record

ArticleEndocrine2026

Pan-immune-inflammation value is associated with thyroid autoantibody positivity in a Chinese health examination cohort.

Yunzhi Chen, Jialin Liao, Wenwen Feng, Yanlian Tan, Haixia Guan, Zixiao Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yunzhi Chen *Department of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, China.
Jialin Liao *Department of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, China.
Wenwen FengDepartment of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, China.
Yanlian TanDepartment of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, China.
Haixia GuanDepartment of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, China. guanhaixia@gdph.org.cn.
Zixiao WangDepartment of Health Management, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China. wangzixiao0109@126.com.

Funding

Natural Science Foundation of Guangdong Province 2024A1515220020
6 · The paper itself

Abstract

purposeAutoimmune thyroid disease (AITD) is associated with adverse health outcomes, yet routine thyroid autoantibody testing may not always be practical in general screening settings. The pan-immune-inflammation value (PIV), derived from complete blood counts, represents a simple, low-cost marker of systemic inflammation. This study investigated the association between PIV and thyroid autoantibody positivity in a health examination cohort.

methodsThis cross-sectional study included 5,785 Chinese adults undergoing routine health examinations at the First Hospital of China Medical University. Associations between PIV and anti-thyroglobulin (TgAb) or anti-thyroid peroxidase (TPOAb) antibody positivity were evaluated using multivariable logistic regression and restricted cubic spline (RCS) models. Subgroup analyses explored interactions with demographic and metabolic factors.

resultsRCS analyses revealed significant non-linear associations between PIV and TgAb (P for non-linearity = 0.002) as well as TPOAb (P = 0.043) positivity. In fully adjusted models, the highest PIV quartile was associated with an increased risk of TgAb positivity compared to the lowest quartile (OR 1.23, 95% CI 1.03-1.47, P = 0.026). The association with TPOAb was borderline significant (P = 0.061). Notably, the relationship was prominent in females and significantly amplified by hypertension (P for interaction = 0.038).

conclusionElevated PIV is non-linearly associated with thyroid autoantibody positivity, particularly TgAb, with stronger effects observed in women and hypertensive individuals. As an inexpensive index derived from routine blood tests, PIV may be a useful adjunctive marker for identifying thyroid autoantibody positivity.

Indexed as

AutoantibodiesInflammationThyroid GlandAdultAgedBiomarkersChinaCohort StudiesCross-Sectional StudiesFemaleHumansIodide PeroxidaseMaleMiddle Agedanti-thyroglobulinanti-thyroid autoantibodiesAutoantibodiesBiomarkersIodide PeroxidasePan-immune-inflammation valueSystemic inflammationTgAbThyroid autoimmunityTPOAb

Identifiers

PMID42545538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.