ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Moving toward precision communication in pediatric oncology clinical trials: An outline of a conceptual framework to support caregiver decision-making.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric oncology clinical trials (POCTs) are the cornerstone of therapeutic progress in childhood cancer. Yet, poor accrual and retention remain persistent challenges contributing to early termination of POCTs, limiting the advancement of novel therapies. These challenges reflect a convergence of system, protocol, clinician, and family-level factors, among which caregivers' psychosocial decision-making processes represent a potentially modifiable but underexplored contributor. Caregivers making POCT-related decisions must navigate complex medical information under conditions of heightened emotional distress and uncertainty. Psychosocial factors such as distress, comprehension, trust, values, and social context are known to influence decision-making. However, the field still lacks an integrated framework to explain how these factors may shape decisional trajectories and outcomes throughout POCT participation. This commentary reframes POCT enrollment not as a discrete informed-consent event, but as a dynamic, psychosocial decision-making process that unfolds over time. We present an outline of a conceptual Precision Communication Framework designed to support care teams in aligning communication priorities with caregivers' psychosocial and decisional contexts at key decision points throughout trial participation. Rather than seeking to address all causes of poor accrual or withdrawal, this framework focuses on reducing preventable decisional uncertainty and regret in contexts where psychosocial processes are central drivers of caregiver experiences. By presenting an outline of a conceptual model that would link psychosocial-decisional profiles to communication strategies to prioritize, this commentary aims to inform future empirical research and lay the groundwork for identifying communication strategies to prioritize to reduce caregiver decisional burden and promote sustained participation in POCTs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.